Rabbit Secondary Antibodies
Jackson Immuno Research Labs DyLight 405-AffiniPure Rabbit Anti-Human IgA+IgG+IgM (H+L)
DyLight 405-AffiniPure Rabbit Anti-Human IgA+IgG+IgM (H+L)
ABclonal Technology 450 Rabbit anti-Human CD138
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family The syndecans mediate cell binding cell signaling and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins Altered syndecan-1 expression has been detected in several different tumor types While several transcript variants may exist for this gene the full-length natures of only two have been described to date These two represent the major variants of this gene and encode the same protein
ABclonal Technology APC Rabbit anti-Human CD1B mAb
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail and requires vesicular acidification to bind lipid antigens
ABclonal Technology 647 Rabbit anti-Human CD70
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF27 CD27 It is a surface antigen on activated but not on resting T and B lymphocytes It induces proliferation of costimulated T cells enhances the generation of cytolytic T cells and contributes to T cell activation This cytokine is also reported to play a role in regulating B-cell activation cytotoxic function of natural killer cells and immunoglobulin sythesis
ABclonal Technology 647 Rabbit anti-Human PTH1R
The protein encoded by this gene is a member of the G-protein coupled receptor family 2 This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH) The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system Defects in this receptor are known to be the cause of Jansen s metaphyseal chondrodysplasia (JMC) chondrodysplasia Blomstrand type (BOCD) as well as enchodromatosis Two transcript variants encoding the same protein have been found for this gene
ABclonal Technology 488 Rabbit anti-Human Nectin-4
Nectin-4 poliovirus Receptor-like 4 (PVRL4) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily that promotes intercellular adhesion by acting as a major component of adhesion junctions The extracellular domain of Nectin-4 consists of one Ig variable region (V) and two Ig constant regions (C) which mediate binding to measles virus and adjacent cells through trans-heterophile interactions with Nectin-1 Unlike other members of the connectin family which are widely expressed in adult tissues human Nectin-4 expression is largely limited to the blastoderm Studies have shown that Nectin-4 is overexpressed in cells from a variety of human solid tumors including pancreatic breast lung and ovarian cancers The expression pattern of Nectin-4 in normal tissues is limited so NECTIN-4 can be used as a novel therapeutic target for various human tumors
ABclonal Technology 647 Rabbit anti-Human CD94
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Three transcript variants encoding two different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human FAP
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family It is selectively expressed in reactive stromal fibroblasts of epithelial cancers granulation tissue of healing wounds and malignant cells of bone and soft tissue sarcomas This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development tissue repair and epithelial carcinogenesis Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human CD200R
This gene encodes a receptor for the OX-2 membrane glycoprotein Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner Alternative splicing of this gene results in multiple transcript variants
ABclonal Technology 594 Rabbit anti-Human CD200R
This gene encodes a receptor for the OX-2 membrane glycoprotein Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner Alternative splicing of this gene results in multiple transcript variants
ABclonal Technology 647 Rabbit anti-Human CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 488 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology GPR55 Rabbit pAb
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways.
ABclonal Technology GPR55 Rabbit pAb
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways.
ABclonal Technology APC Rabbit anti-Human CD153
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF8 CD30 which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch This cytokine was shown to enhance cell proliferation of some lymphoma cell lines while to induce cell death and reduce cell proliferation of other lymphoma cell lines The pleiotropic biologic activities of this cytokine on different CD30 lymphoma cell lines may play a pathophysiologic role in Hodgkin s and some non-Hodgkin s lymphomas Two transcript variants encoding different isoforms have been found for this gene